Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: Derivation of a clinical algorithm
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Author's response to reviews Title: Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: Derivation of a clinical algorithm Authors:
Werner C Albrich ([email protected]) Frank Dusemund ([email protected]) Kristina Rüegger ([email protected]) Mirjam Christ-Crain ([email protected]) Werner Zimmerli ([email protected]) Thomas Bregenzer ([email protected]) Sarosh Irani ([email protected]) Ulrich Bürgi ([email protected]) Barbara Reutlinger ([email protected]) Beat Müller (happy...
متن کاملEnhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: Derivation of a clinical algorithm
BACKGROUND Proadrenomedullin (ProADM) confers additional prognostic information to established clinical risk scores in lower respiratory tract infections (LRTI). We aimed to derive a practical algorithm combining the CURB65 score with ProADM-levels in patients with community-acquired pneumonia (CAP) and non-CAP-LRTI. METHODS We used data of 1359 patients with LRTI enrolled in a multicenter st...
متن کاملEffectiveness of Proadrenomedullin Enhanced CURB65 Score Algorithm in Patients with Community-Acquired Pneumonia in “Real Life”, an Observational Quality Control Survey
BACKGROUND An intervention trial found a trend for shorter length of stay (LOS) in patients with community-acquired pneumonia (CAP) when the CURB65 score was combined with the prognostic biomarker proadrenomedullin (ProADM) (CURB65-A). However, the efficacy and safety of CURB65-A in real life situations remains unclear. METHODS From September, 2011, until April, 2012, we performed a post-stud...
متن کاملProhormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
INTRODUCTION Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI). METHODS We assessed clinical parameters and five biomarkers, the precursor levels of adrenomedullin (ADM), endothelin-1 (ET1), atrial-natriuretic peptide (ANP), anti...
متن کاملLower respiratory tract infections.
Acute lower respiratory infections (ALRI) are the major cause of morbidity and mortality in young children worldwide. ALRIs are important indicators of the health disparities that persist between Indigenous and non-Indigenous children in developed countries. Bronchiolitis and pneumonia account for the majority of the ALRI burden. The epidemiology, diagnosis, and management of these diseases in ...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2011
ISSN: 1471-2334
DOI: 10.1186/1471-2334-11-112